Graham Dorrans' first-half stunner earned West Bromwich Albion a 1-0 victory over QPR at The Hawthorns.
Rangers were backed by a 2,700-strong travelling contingent from West London but were unable to build on Wednesday night's impressive win over Swansea City in W12.
Dorrans struck midway through the first half to hand the Baggies all three points, with his 30-yard blast flashing into the top left-hand corner, despite a touch from Paddy Kenny.
The R's had numerous chances to level, namely through Bobby Zamora - but Dorrans' opener ultimately proved decisive.
Rangers boss Hughes made one change to his side for the trip to the Midlands, with Shaun Derry returning to the side - that after sitting out of our win over Swansea through suspension - at the expense of Akos Buzsaky
Kenny was in goal for the R's, in a 4-5-1 formation.
Nedum Onuoha, Anton Ferdinand, Clint Hill and Taye Taiwo lined up in defence.
Joey Barton, Derry and Samba Diakite made up a three-man central midfield for QPR, with Mackie and Adel Taarabt occupying the wide positions.
Zamora led the line for the Hoops in attack.
West Brom were dealt a blow prior to kick-off when stopper Jonas Olsson - originally named in the Baggies' starting XI - was injured in the pre-match warm-up. Craig Dawson took his place.
A man down, hosts Albion were almost a goal behind too after just three minutes when Hill's header forward put Zamora in the clear, only for Foster to thwart the former Fulham ace with a smart block.
The Baggies fashioned their first chance on eight minutes. Derry was dispossessed by Marc-Antoine Fortune before freeing Peter Odemwingie in the box, whose snap shot whistled just inches wide of the right-hand post.
It was the home side who were on top in terms of possession inside the opening stanza, even though Odemwingie's wayward effort from distance was all they had to show for a spell of early pressure.
But a Baggies breakthrough would eventually arrive on 22 minutes - and what an effort it proved to be.
Odemwingie fed Dorrans 30 yards from goal before the cultured Scot unleashed a bullet effort, seeing his shot flying into the top left-hand corner- albeit after a touch from Kenny.
Creator of West Brom's opener, Odemwingie almost got himself on the score-sheet 14 minutes before the break, racing clear down the right before drilling a low shot just wide.
Rangers produced their best effort of the first half yet two minutes later.
Taarabt's defence-splitting pass found Mackie on the right, who drove towards the target before his ball into the box ended in Diakite clattering an effort into the side-netting.
If that was close, the R's went even nearer in the 39th minute.
Derry's intervention saw the ball trickle to Barton on the right-hand edge of the box, before his dinked centre was crashed wide of goal by the head of Zamora.
This was much better from Hughes's men, who went close again just a minute later when Taiwo's spectacular long pass put Zamora through on goal.
But Ben Foster was equal to the forward's subsequent effort, pulling a fine save to preserve West Brom's lead. Mackie, meanwhile, almost levelled on the stroke of half-time, showing tremendous strength to hold off his marker before dragging an effort just inches beyond the post.
Buoyed by their end to the opening period, Rangers made a positive start to the second half.
The visitors were, however, fortunate to be just a goal down when Albion struck the post on 55 minutes.
Odemwingie's back-heel found Billy Jones in the penalty area, whose resultant effort cannoned back off the frame of the goal.
Looking for an equaliser, Hughes introduced Shaun Wright-Phillips in place of Derry on 57 minutes to give QPR more options at the top end of the pitch. Three minutes later, Barton saw an effort from a Taarabt corner sail past the upright.
And the R's skipper was again involved on 62 minutes, capitalising on a miscued clearance from Taiwo's cross before shooting wide.
Rangers should have levelled in the 75th minute.
Zamora started and finished the move, cushioning a long ball down for Taarabt before the Moroccan's low centre was dragged wide via the back of Mackie.
West Bromwich Albion: Foster, Ridgewell, Brunt, Thomas (Scharner 81), Dorrans (Andrews 71), Mulumbu, McAuley, Odemwingie, Dawson, Jones, Fortune (Long 59).
Subs: Daniels, Shorey, Hurst, Cox.
Goals: Dorrans (22)
Bookings: Mulumbu (51), Ridgewell (61), Dorrans (70)
QPR: Kenny, Diakite, Hill, Derry (Wright-Phillips 57), Taarabt (Helguson 75), Mackie, Barton, Taiwo (Traore 77), Ferdinand, Onuoha, Zamora.
Subs: Cerny, Gabbidon, Buzsaky, Young.
Bookings: Diakite (56)
Referee: Mr J Moss