Goals from Wayne Rooney and Paul Scholes gave Manchester United a 2-0 victory over ten-man QPR at Old Trafford.
In a match not without controversy, United were in front thanks to a disputed penalty on 15 minutes, after Shaun Derry clashed with Ashley Young.
Video replays showed that there was minimal contact between the two, while Young was in an offside position.
Derry, meanwhile, was sent off by referee Mr Mason, before Rooney stepped up to smash home from 12 yards.
The R's were brave in the second period but saw their challenge effectively ended in the 68th minute, after Scholes's outstanding 20-yard effort flew into the bottom left-hand corner.
Mindful of the fact that QPR were set to contest three Barclays Premier League matches in the space of just six days, Hughes made two changes to his starting XI for the trip to Manchester.
Akos Buzsaky and Jay Bothroyd came into the side, replacing Joey Barton and Bobby Zamora respectively.
Rangers did, however, stick with the 4-5-1 formation deployed in our 2-1 win over Arsenal last weekend, with Paddy Kenny in goal.
Nedum Onuoha, Anton Ferdinand, Clint Hill and Taye Taiwo began in defence.
Buzsaky, Derry and Samba Diakite started in central midfield, with Jamie Mackie and Adel Taarabt occupying the wings.
Bothroyd played the lone striker role in attack.
United made a dominant start and went close inside five minutes, after Rooney's free-kick was deflected wide when Hill originally felled Danny Wellbeck 25 yards from goal.
Rooney soon went closer, this time forcing a stunning save from Kenny, again from a set-piece situation.
Controversy sparked on 14 minutes, after the home side were awarded a disputed penalty - and Rangers were reduced to ten men.
Rooney's through pass into Young saw the latter go down under minimal contact from Derry in the box.
Incidentally, videos replays also showed that Young was in an offside position.
Derry was subsequently given his marching orders, before Rooney stepped up a minute later to slam home from the spot.
Despite being a man light, the R's - who admittedly had to endure a constant stream of United pressure - did settle.
Taarabt went close for the visitors on 21 minutes, seeing his deflected shot tipped over the bar by David De Gea.
Three minutes later, the Reds missed a golden chance to double their lead, after Young somehow nodded Rooney's cross wide from close range.
At the other end, Taarabt forced a fine last-ditch block from Jonny Evans - who the Moroccan originally dispossessed - before Kenny gathered an audacious attempted lob by Rooney.
Rangers were having to hang on just before the break, but did enough to keep the margin to just a single goal.
Wellbeck headed over from Antonio Valencia's cross seven minutes before half-time, while Patrice Evra saw an effort trickle inches wide of the right-hand post.
Scholes then saw his first-half stoppage time attempt fly just past the upright.
United thought they'd extended their advantage two mintues after half-time, after Welbeck touched home from close range. The England ace's strike, however, was ruled out for offside.
Welbeck was again involved just two minutes later, blazing over following Young's clever back-heel.
Despite the numerical disadvantage, QPR showed magnificent heart throughout and went close on 56 minutes, with the energetic Diakite seeing a shot deflected just wide of goal.
Rangers had Kenny to thank for keeping them in the contest on 59 minutes.
Scholes freed Rafael, before the United full-back's close-range blast was somehow tipped on to the bar by Kenny.
And the R's keeper was at it again soon after, twice saving excellently well from Welbeck.
The contest was settled when United added a second on 68 minutes.
Rafael benefited from Taarabt's mis-control, before Scholes's wonderful drive from 20 yards sailed into the bottom left-hand corner.
Manchester United: De Gea, Evra, Evans, Ferdinand, Rafael (Jones 74), Valencia, Carrick, Scholes (Cleverley 74), Rooney, Young (Giggs 62), Welbeck.
Subs: Amos, Park Ji-sung, Pogba, Hernandez.
Goals: Rooney (pen 15), Scholes (68)
Bookings: Rafael (78)
QPR: Kenny, Diakite (Wright-Phillips 71), Hill, Derry, Taarabt (Smith 71), Bothroyd (Campbell 81), Mackie, Buzsaky, Taiwo, Ferdinand, Onuoha.
Subs: Cerny, Gabbidon, Young, Zamora.
Red Cards: Derry (14)
Referee: Mr L Mason