A sublime solo goal from Kieron St Aimie settled a keenly contested affair at Adams Park.
The Rangers youngster bagged the only goal of the game in the 13th minute, on an afternoon when Michael Mancienne played 45 minutes on his comeback from injury.
St Aimie lit up an otherwise drab first period with the one real piece of attacking magic, as the R's Reserves clocked up a maiden away victory of their Pontins Holidays Combination League campaign.
Wycombe started on the front foot at Adams Park, with Jake Cole forced to tip the roaming Robbie Rice's 25-yard effort over the bar inside the opening two minutes.
But Rangers, despite losing Sampsa Timoska to a knee injury early on, soon stamped their authority on proceedings.
St Aimie showed why he's so highly rated when he bagged an impressive individual goal in the 13th minute.
Intercepting a loose pass inside his own half, the teenager showed astounding pace to sprint clear of a static Wanderers back line before sending a composed 15-yard past the exposed Przemyslaw Kazimierczak.
Buoyed by their goal, the R's went on to enjoy the lion's share of possession in the remainder of the half.
Andrew Howell played provider for the visitors' next opportunity, when Shabazz Baidoo fired his enticing far post cross wide.
At the other end, Derek Duncan headed high and wide, before Stefan Moore saw his close range prod deflected wide seven minutes before the break.
Mancienne, on his comeback from a six-week absence, made way for Matt O'Brien at the break, with the Rangers backroom staff earmarking a return to first team duties for the Chelsea loanee for the visit of Ipswich Town to Loftus Road this weekend.
Similar to the first period, it was the hosts who created the first chance of the half, when Cole dived low to his right to smother Calum Botham's shot on the turn.
Rangers should have made sure of the three points in the 53rd minute, only for Baidoo to fire straight at Kazimierczak after he capitalised on a defensive error to coast clean through on goal.
With first team opportunities scarce so far this season, Cole was determined to prove a point between the sticks and he did himself no harm whatsoever when he palmed away Reuben Reid's speculative long range effort, before gathering at the second attempt.
Reid was proving a constant threat and the powerful striker should have put Wycombe on terms in the 70th minute, only to nod his free back post header over the bar.
Rangers handed a Reserve team debut to Under-18 striker Angelo Balanta late on, but despite a few nice touches, he was unable to show his true potential in a scrappy ending.
Wycombe Wanderers Res: Kazimierczak, Rice, Woodman, Boucaud, Christon, Antwi, Phillips, Shulton, Reid, Botham, Duncan.
Subs: Crooks, Obersteller, Daly, Holloway, Fitchett.
QPR Res: Cole, Bignot, Howell, Cullip, Shimmin, Mancienne (O'Brien 46), Timoska (Arthur 13), Curtis, Baidoo (Balanta 80), Moore, St Aimie.
Subs: Crowther, Rose.
